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Fungal CSL transcription factors

Authors
  • Převorovský, Martin1
  • Půta, František1
  • Folk, Petr1
  • 1 Charles University in Prague, Department of Physiology and Developmental Biology, Faculty of Science, Viničná 7, Praha 2, CZ 128 44, Czech Republic , Praha 2
Type
Published Article
Journal
BMC Genomics
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Jul 13, 2007
Volume
8
Issue
1
Identifiers
DOI: 10.1186/1471-2164-8-233
Source
Springer Nature
Keywords
License
Yellow

Abstract

BackgroundThe CSL (C BF1/RBP-Jκ/S uppressor of Hairless/L AG-1) transcription factor family members are well-known components of the transmembrane receptor Notch signaling pathway, which plays a critical role in metazoan development. They function as context-dependent activators or repressors of transcription of their responsive genes, the promoters of which harbor the GTG(G/A)GAA consensus elements. Recently, several studies described Notch-independent activities of the CSL proteins.ResultsWe have identified putative CSL genes in several fungal species, showing that this family is not confined to metazoans. We have analyzed their sequence conservation and identified the presence of well-defined domains typical of genuine CSL proteins. Furthermore, we have shown that the candidate fungal protein sequences contain highly conserved regions known to be required for sequence-specific DNA binding in their metazoan counterparts. The phylogenetic analysis of the newly identified fungal CSL proteins revealed the existence of two distinct classes, both of which are present in all the species studied.ConclusionOur findings support the evolutionary origin of the CSL transcription factor family in the last common ancestor of fungi and metazoans. We hypothesize that the ancestral CSL function involved DNA binding and Notch-independent regulation of transcription and that this function may still be shared, to a certain degree, by the present CSL family members from both fungi and metazoans.

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