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Functional tissue units and their primary tissue motifs in multi-scale physiology.

Authors
Type
Published Article
Journal
Journal of Biomedical Semantics
2041-1480
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
4
Issue
1
Pages
22–22
Identifiers
DOI: 10.1186/2041-1480-4-22
PMID: 24103658
Source
Medline

Abstract

Multi-organ communication, therefore, may be interpreted in terms of interactions between molecular networks housed by interconnected functional tissue units. By extension, a functional picture of an organ, or its tissue components, may be rationally assembled using a collection of these functional tissue units as building blocks. In our work, we outline the biophysical rationale for a rigorous definition of a unit of functional tissue organization, and demonstrate the application of primary motifs in tissue classification. In so doing, we acknowledge (i) the fundamental role of capillaries in directing and radically informing tissue architecture, as well as (ii) the importance of taking into full account the critical influence of neighbouring cellular environments when studying complex developmental and pathological phenomena.

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