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The Functional Role of Prostate Cancer Metastasis-related Micro-RNAs.

Authors
  • Weidle, Ulrich H1
  • Epp, Alexandra2
  • Birzele, Fabian3
  • Brinkmann, Ulrich1
  • 1 Roche Pharma Research and Early Development, Roche Innovation Center Munich, Penzberg, Germany [email protected] [email protected] , (Germany)
  • 2 Roche Pharma Research and Early Development, Roche Innovation Center Munich, Penzberg, Germany. , (Germany)
  • 3 Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, Basel, Switzerland. , (Switzerland)
Type
Published Article
Journal
Cancer Genomics & Proteomics
Publisher
International Institute of Anticancer Research
Publication Date
Jan 01, 2019
Volume
16
Issue
1
Pages
1–19
Identifiers
DOI: 10.21873/cgp.20108
PMID: 30587496
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The mortality of patients with hormone-resistant prostate cancer can be ascribed to a large degree to metastasis to distant organs, predominantly to the bones. In this review, we discuss the contribution of micro-RNAs (miRs) to the metastatic process of prostate cancer. The criteria for selection of miRs for this review were the availability of preclinical in vivo metastasis-related data in conjunction with prognostic clinical data. Depending on their function in the metastatic process, the corresponding miRs are up- or down-regulated in prostate cancer tissues when compared to matching normal tissues. Up-regulated miRs preferentially target suppressors of cytokine signaling or tumor suppressor-related genes and metastasis-inhibitory transcription factors. Down-regulated miRs promote epithelial-mesenchymal transition or mesenchymal-epithelial transition and diverse pro-metastatic signaling pathways. Some of the discussed miRs exert their function by simultaneously targeting epigenetic pathways as well as cell-cycle-related, anti-apoptotic and signaling-promoting targets. Finally, we discuss potential therapeutic options for the treatment of prostate cancer-related metastases by substitution or inhibition of miRs. Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

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