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Functional Role of Methionine Oxidation in Proteins: Arguments for and against

Authors
  • Rosenfeld, M. A.1
  • Yurina, L. V.1
  • Vasilyeva, A. D.1
  • 1 Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia , Moscow (Russia)
Type
Published Article
Journal
Biology Bulletin Reviews
Publisher
Pleiades Publishing
Publication Date
Dec 01, 2021
Volume
11
Issue
Suppl 1
Pages
1–18
Identifiers
DOI: 10.1134/S2079086421070070
Source
Springer Nature
Keywords
Disciplines
  • Article
License
Yellow

Abstract

Abstract—The conversion of methionine to methionine sulfoxide (MetO) is one of the most common oxidative modifications in proteins due to the special susceptibility of methionine to oxidative conditions. Methionine oxidation can affect the protein structure and function, while the level of MetO increases with the development of oxidative stress. Most cells contain methionine sulfoxide reductases (MSRs), which catalyze a thioredoxin-dependent reduction of methionine sulfoxide to the original methionine. It was demonstrated that mutations leading to a decrease in MSR activity are associated with a decrease in the resistance of some cells to oxidative stress, while mutations leading to an overproduction of MSR activity result in an increase in resistance to oxidative stress. The redox reactions of methionines in the functional regulation of some intracellular proteins, actin, and calmodulin, are analyzed in the work, and the presence of antioxidant methionines in intracellular proteins, such as glutamine synthetase, 15-lipoxygenase, recombinant proteins, interferon α-2b, tissue plasminogen activator, and human stem cell factor, is discussed. The absence of MSR in the blood plasma makes the oxidation of methionines in the proteins irreversible; therefore, the ability of methionines to serve as interceptors of oxidant molecules without impairment of the function of plasma proteins is quite controversial. Antioxidant methionines were found in a number of proteins, such as macroglobulin, antithrombin III, and blood coagulation factor XIII. However, no antioxidant methionines were detected for most blood plasma proteins. There is a correlation between the oxidation of methionines and the development of pathological conditions in the organism.

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