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Functional responsiveness of memory T cells from COVID-19 patients

Authors
  • Tavukcuoglu, Ece1
  • Horzum, Utku1
  • Cagkan Inkaya, Ahmet2
  • Unal, Serhat2
  • Esendagli, Gunes1
  • 1 Department of Basic Oncology, Hacettepe University Cancer Institute, Ankara, Turkey
  • 2 Department of Infectious Diseases, Faculty of Medicine, Hacettepe University, Ankara, Turkey
Type
Published Article
Journal
Cellular Immunology
Publisher
Elsevier
Publication Date
Apr 17, 2021
Volume
365
Pages
104363–104363
Identifiers
DOI: 10.1016/j.cellimm.2021.104363
PMID: 33905951
PMCID: PMC8052500
Source
PubMed Central
Keywords
Disciplines
  • Short Communication
License
Unknown

Abstract

The presence of memory T cells in COVID-19 patients has been acknowledged, however the functional potency of memory responses is critical for protection. In this study, naïve, effector, effector memory, and central memory CD4+ and CD8+ T cells obtained from the COVID-19 survivors were re-exposed to autologous monocyte-derived DCs that were loaded with SARS-CoV-2 spike glycoprotein S1. Proliferation capacity, CD25, 4-1BB, and PD-1 expression, and IFN-γ, IL-6, granzyme, granulysin, and FasL secretion were enhanced in CD4+ and CD8+ effector memory and central memory T cells. Albeit being at heterogeneous levels, the memory T cells from the individuals with COVID-19 history possess functional capacities to reinvigorate anti-viral immunity against SARS-CoV-2.

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