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[Functional imaging in idiopathic generalized epilepsy].

Authors
Type
Published Article
Journal
Revue Neurologique
0035-3787
Publisher
Elsevier
Publication Date
Volume
154
Issue
10
Pages
691–693
Identifiers
PMID: 9846339
Source
Medline
License
Unknown

Abstract

Positron emission tomography has offered the possibility to investigate the pathophysiology of idiopathic generalized epilepsies. Absence epilepsies demonstrate normal cerebral glucose metabolism and benzodiazepine receptor density. Conversely, juvenile myoclonic epilepsies are associated with frontal hypometabolism, which aggravates during a working memory task. Typical 3 Hz spike and wave discharges lead to a diffuse hypermetabolism. The latter resembles that observed during GAERS rats absences, and clearly differs from the hypometabolism encountered in partial epilepsies associated with generalized spike and wave discharges. Overall, functional imaging data provide further evidence of syndromic specificities in idiopathic generalized epilepsies.

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