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Functional evidence that the Ser-195 residue of staphylococcal exfoliative toxin A is essential for biological activity.

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PMC
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  • Biology
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Abstract

The substitution of the serine 195 residue of staphylococcal exfoliative toxin A by a cysteine residue led to a biologically inactive protein. This result is consistent with the hypothesis that exfoliative toxin A could be a protease or a lipase. However, no protease or lipase activity was detected with the native toxin.

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