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Functional connectivity disturbances of the ascending reticular activating system in temporal lobe epilepsy.

Authors
  • Englot, Dario J1, 2
  • D'Haese, Pierre-Francois3
  • Konrad, Peter E1
  • Jacobs, Monica L4
  • Gore, John C2, 5
  • Abou-Khalil, Bassel W6
  • Morgan, Victoria L2, 5
  • 1 Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • 2 Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • 3 Department of Electrical Engineering, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • 4 Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • 5 Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • 6 Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Type
Published Article
Journal
Journal of Neurology Neurosurgery & Psychiatry
Publisher
BMJ
Publication Date
Nov 01, 2017
Volume
88
Issue
11
Pages
925–932
Identifiers
DOI: 10.1136/jnnp-2017-315732
PMID: 28630376
Source
Medline
Keywords
License
Unknown

Abstract

Recurrent seizures in TLE are associated with disturbances in ARAS connectivity, which are part of the widespread network dysfunction that may be related to neurocognitive problems in this devastating disorder.

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