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Functional clonal deletion of class I-specific cytotoxic T lymphocytes by veto cells that express antigen.

Authors
  • Rammensee, H G
  • Fink, P J
  • Bevan, M J
Type
Published Article
Journal
Journal of immunology (Baltimore, Md. : 1950)
Publication Date
Nov 01, 1984
Volume
133
Issue
5
Pages
2390–2396
Identifiers
PMID: 6207228
Source
Medline
License
Unknown

Abstract

Intravenous injection of class I incompatible spleen cells into mice results in a drastic reduction of the recipient's cytotoxic T lymphocyte (CTL) response against the injected, but not against third party, class I antigens when measured in bulk cultures initiated 5 to 6 days after the injection. This specific suppressive effect is partly due to T cells but can also be seen when high numbers of anti-Thy-1 and complement-treated spleen cells of nude mice are injected. Such cells suppressing CTL responses against self histocompatibility antigens are called "veto cells." The precursor frequency of CTL specific for the injected class I antigen is found to be reduced greater than 200-fold at days 5 to 6 after the injection, whereas the frequencies of CTL specific for third party class I antigens are not significantly changed. These results indicate that there is a functional clonal deletion of the CTL recognizing class I incompatible veto cells in vivo. The role of such a veto phenomenon in the induction and maintenance of self tolerance and allograft tolerance is discussed.

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