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Functional characterization of an orphan nuclear receptor, Rev-ErbAalpha, in chondrocytes and its potential role in osteoarthritis.

Authors
  • Chaturvedi, P1
  • Pratta, M
  • Steplewski, K
  • Connor, J
  • Kumar, S
  • 1 Microbial, Musculoskeletal, and Proliferative Diseases, GlaxoSmithKline, Collegeville, Pennsylvania 19426, USA. [email protected]
Type
Published Article
Journal
Arthritis and rheumatism
Publication Date
November 2006
Volume
54
Issue
11
Pages
3513–3522
Identifiers
PMID: 17075855
Source
Medline
License
Unknown

Abstract

This study is the first to demonstrate that Rev-ErbAalpha is highly expressed in OA articular chondrocytes and that its expression is modulated by known cartilage catabolic and anabolic stimuli. We also demonstrated that modulation of Rev-ErbAalpha expression in chondrocytes may be a novel means of regulating the expression and production of multiple matrix-degrading enzymes. These observations suggest that Rev-ErbAalpha may be a novel therapeutic target for OA.

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