Affordable Access

Functional characterization of an orphan nuclear receptor, Rev-ErbAalpha, in chondrocytes and its potential role in osteoarthritis.

Authors
  • 1
Type
Published Article
Journal
Arthritis & Rheumatism
0004-3591
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
54
Issue
11
Pages
3513–3522
Identifiers
PMID: 17075855
Source
Medline

Abstract

This study is the first to demonstrate that Rev-ErbAalpha is highly expressed in OA articular chondrocytes and that its expression is modulated by known cartilage catabolic and anabolic stimuli. We also demonstrated that modulation of Rev-ErbAalpha expression in chondrocytes may be a novel means of regulating the expression and production of multiple matrix-degrading enzymes. These observations suggest that Rev-ErbAalpha may be a novel therapeutic target for OA.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments
F