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Functional analysis of the chromosome 9p21.3 coronary artery disease risk locus.

Authors
  • Jarinova, Olga
  • Stewart, Alexandre F R
  • Roberts, Robert
  • Wells, George
  • Lau, Paulina
  • Naing, Thet
  • Buerki, Christine
  • McLean, Bradley W
  • Cook, Richard C
  • Parker, Joel S
  • McPherson, Ruth
Type
Published Article
Journal
Arteriosclerosis Thrombosis and Vascular Biology
Publisher
Ovid Technologies Wolters Kluwer -American Heart Association
Publication Date
Oct 01, 2009
Volume
29
Issue
10
Pages
1671–1677
Identifiers
DOI: 10.1161/ATVBAHA.109.189522
PMID: 19592466
Source
Medline
License
Unknown

Abstract

These findings are consistent with the hypothesis that the 9p21.3 risk allele contains a functional enhancer, the activity of which is altered in carriers of the risk allele. 9p21.3 may promote atherosclerosis by regulating expression of ANRIL, which in turn is associated with altered expression of genes controlling cellular proliferation pathways.

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