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Function of the respiratory syncytial virus small hydrophobic protein.

Authors
  • Fuentes, Sandra1
  • Tran, Kim C
  • Luthra, Priya
  • Teng, Michael N
  • He, Biao
  • 1 Center of Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, 115 Henning Bldg., University Park, PA 16802, USA.
Type
Published Article
Journal
Journal of virology
Publication Date
August 2007
Volume
81
Issue
15
Pages
8361–8366
Identifiers
PMID: 17494063
Source
Medline
License
Unknown

Abstract

Respiratory syncytial virus (RSV), a member of the Paramyxoviridae family, encodes a small hydrophobic (SH) protein of unknown function. Parainfluenza virus 5 (PIV5), a prototypical paramyxovirus, also encodes an SH protein, which inhibits tumor necrosis factor alpha (TNF-alpha) signaling. In this study, recombinant PIV5 viruses without their own SH but containing RSV SH (from RSV strain A2 or B1) in its place (PIV5DeltaSH-RSV SH) and RSV lacking its own SH (RSVDeltaSH) were generated and analyzed. The results indicate that the SH protein of RSV has a function similar to that of PIV5 SH and that it can inhibit TNF-alpha signaling.

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