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The function of the NineTeen Complex (NTC) in regulating spliceosome conformations and fidelity during pre-mRNA splicing.

Authors
Type
Published Article
Journal
Biochemical Society Transactions
1470-8752
Publisher
Portland Press
Publication Date
Volume
38
Issue
4
Pages
1110–1115
Identifiers
DOI: 10.1042/BST0381110
PMID: 20659013
Source
Medline
License
Unknown

Abstract

The NineTeen Complex (NTC) of proteins associates with the spliceosome during pre-mRNA splicing and is essential for both steps of intron removal. The NTC and other NTC-associated proteins are recruited to the spliceosome where they participate in regulating the formation and progression of essential spliceosome conformations required for the two steps of splicing. It is now clear that the NTC is an integral component of active spliceosomes from yeast to humans and provides essential support for the spliceosomal snRNPs (small nuclear ribonucleoproteins). In the present article, we discuss the identification and characterization of the yeast NTC and review recent work in yeast that supports the essential role for this complex in the regulation and fidelity of splicing.

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