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Fumagillin: an anti-infective as a parent molecule for novel angiogenesis inhibitors.

Authors
  • Lefkove, Benjamin
  • Govindarajan, Baskaran
  • Arbiser, Jack L
Type
Published Article
Journal
Expert Review of Anti-infective Therapy
Publisher
"Informa Healthcare (Expert Reviews, LTD)"
Publication Date
Aug 01, 2007
Volume
5
Issue
4
Pages
573–579
Identifiers
PMID: 17678422
Source
Medline
License
Unknown

Abstract

Fumagillin is an active amebicide and anti-infective isolated from the fungus Aspergillus fumigatus. Since its characterization in 1951, fumagillin has been studied extensively for its anti-infective properties. Although fumagillin is not approved for systemic use in the USA, this compound has one of the highest efficacies for the treatment of microsporidial infections in HIV-positive patients. Fumagillin does exhibit some side effects that have deterred its acceptance as a viable treatment, but the current body of research on the synthesis of novel analogs of this molecule shows an exciting and promising revival of this drug as both an anti-infective and antiangiogenic agent.

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