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Fucosterol, isolated from Ecklonia stolonifera, inhibits adipogenesis through modulation of FoxO1 pathway in 3T3-L1 adipocytes.

Authors
  • Lee, Ji-Hyun1
  • Jung, Hyun Ah2
  • Kang, Min Jae1
  • Choi, Jae Sue3
  • Kim, Gun-Do1
  • 1 Department of Microbiology, College of Natural Sciences, Pukyong National University, Busan, Korea.
  • 2 Department of Food Science and Human Nutrition, College of Environmental and Bioresource Sciences, Chonbuk National University, Jeonju, Korea.
  • 3 Department of Food and Life Science, College of Fisheries Sciences, Pukyong National University, Busan, Korea.
Type
Published Article
Journal
The Journal of pharmacy and pharmacology
Publication Date
Jan 30, 2017
Identifiers
DOI: 10.1111/jphp.12684
PMID: 28134973
Source
Medline
Keywords
License
Unknown

Abstract

We revealed that fucosterol inhibited adipogenesis of 3T3-L1 preadipocytes through modulation of FoxO signalling pathway. Therefore, our results suggest that fucosterol may be used for novel agents for the treatment of obesity.

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