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Fuchs endothelial corneal dystrophy.

Authors
  • Elhalis, Hussain1
  • Azizi, Behrooz
  • Jurkunas, Ula V
  • 1 Schepens Eye Research Institute, Boston, MA 02114, USA.
Type
Published Article
Journal
The ocular surface
Publication Date
Oct 01, 2010
Volume
8
Issue
4
Pages
173–184
Identifiers
PMID: 20964980
Source
Medline
License
Unknown

Abstract

Fuchs endothelial corneal dystrophy (FECD) is characterized by progressive loss of corneal endothelial cells, thickening of Descement's membrane and deposition of extracellular matrix in the form of guttae. When the number of endothelial cells becomes critically low, the cornea swells and causes loss of vision. The clinical course of FECD usually spans 10-20 years. Corneal transplantation is currently the only modality used to restore vision. Over the last several decades genetic studies have detected several genes, as well as areas of chromosomal loci associated with the disease. Proteomic studies have given rise to several hypotheses regarding the pathogenesis of FECD. This review expands upon the recent findings from proteomic and genetic studies and builds upon recent advances in understanding the causes of this common corneal disorder.

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