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The fruits of Cudrania tricuspidata suppress development of atopic dermatitis in NC/Nga mice.

Authors
  • Lee, Hoyoung1
  • Ha, Hyekyung
  • Lee, Jun Kyung
  • Seo, Chang-Seob
  • Lee, Nam-Hun
  • Jung, Da-Young
  • Park, Sang-Joon
  • Shin, Hyeun Kyoo
  • 1 Herbal Medicine EBM Research Center, Korea Institute of Oriental Medicine, Daejeon 305-811, Korea. , (North Korea)
Type
Published Article
Journal
Phytotherapy Research
Publisher
Wiley (John Wiley & Sons)
Publication Date
Apr 01, 2012
Volume
26
Issue
4
Pages
594–599
Identifiers
DOI: 10.1002/ptr.3577
PMID: 21972057
Source
Medline
License
Unknown

Abstract

The fruits of Cudrania tricuspidata are a medicinal herb in Korea, known for its antiatherosclerotic and antiinflammatory effects. Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by the influx of lymphocytes into the dermis. Using an animal model of AD, we assessed whether C. tricuspidata suppresses the development of AD-like skin lesions. Cudrania tricuspidata was administered orally to NC/Nga mice with Dermatophagoides-farinae-induced AD-like lesions for 49 days. The effects of C. tricuspidata were assessed by measuring clinical symptoms, swelling of the skin on the back and ears, and plasma concentrations of mTARC (mouse thymus and activation regulated chemokine), histamine and immunoglobulin E (IgE). We found that C. tricuspidata (60 mg/kg/day) inhibited the development of AD-like skin lesions, reduced skin dermatitis scores and inhibited the histological changes induced by repeated application of D. farinae. In addition, C. tricuspidata inhibited the increases in plasma concentrations of mTARC, histamine and IgE induced by D. farinae. These findings indicate that C. tricuspidata inhibits the development of AD-like skin lesions induced by repeated applications of D. farinae in sensitized NC/Nga by suppressing plasma concentrations of mTARC, histamine and IgE.

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