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Frontispiece: asymmetric reduction of α-amino ketones with a KBH4 solution catalyzed by Chiral Lewis acids.

Authors
Type
Published Article
Journal
Chemistry - A European Journal
1521-3765
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
20
Issue
42
Identifiers
DOI: 10.1002/chem.201484271
PMID: 25288170
Source
Medline
Keywords
  • N,N′-Dioxide-Metal Complex
  • Alcohols
  • Asymmetric Synthesis
  • Ketones
  • Reduction

Abstract

Asymmetric Alkali Metal Borohydride Reduction Alkali metal borohydrides are mild, inexpensive, highly selective, and environmentally friendly reducing agents in organic chemistry. In their Communication on page 13482 ff., X. Feng et al. demonstrate an efficient enantioselective reduction of both secondary and primary α-amino ketones with potassium borohydride solution catalyzed by chiral N,N'-dioxide-metal complex catalysts. The catalytic system features a convenient operation and tolerance to water, without the need for basic additives.

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