Affordable Access

deepdyve-link
Publisher Website

Frontal-Amygdala Connectivity Alterations During Emotion Downregulation in Bipolar I Disorder

Authors
  • Townsend, Jennifer D.
  • Torrisi, Salvatore J.
  • Lieberman, Matthew D.
  • Sugar, Catherine A.
  • Bookheimer, Susan Y.
  • Altshuler, Lori L.
Type
Published Article
Journal
Biological Psychiatry
Publisher
Elsevier
Publication Date
Jan 01, 2013
Accepted Date
Jun 14, 2012
Volume
73
Issue
2
Pages
127–135
Identifiers
DOI: 10.1016/j.biopsych.2012.06.030
Source
Elsevier
Keywords
License
Unknown

Abstract

BackgroundThe symptoms of bipolar disorder suggest dysfunction of emotion regulatory networks. In healthy control populations, downregulation of emotional responses activates the ventral lateral prefrontal cortex (vlPFC) and dampens amygdala activation. This study investigated frontal and limbic function and connectivity during emotion downregulation in euthymic subjects with bipolar I disorder (BPI) and healthy control subjects. MethodsThirty BPI and 26 control subjects underwent functional magnetic resonance imaging scanning while performing an emotion processing task with passive viewing and emotion downregulation conditions. Contrasts were made for each group comparing the downregulation and passive viewing conditions, and these were entered into a between-group random effects analysis to assess group differences in activation. Psychophysiological interaction analyses were conducted to test for significant group differences in functional connectivity between the amygdala and inhibitory frontal regions (i.e., vlPFC). ResultsControl subjects showed the expected robust bilateral activation of frontal and limbic regions during passive viewing and emotion downregulation tasks. Between-group analyses revealed similar activation of BPI and control subjects during passive viewing but significantly decreased activation in bilateral vlPFC, bilateral anterior and posterior cingulate, medial frontal gyrus, and bilateral dorsal lateral prefrontal cortex during emotion downregulation in subjects with BPI. Connectivity analysis demonstrated that control subjects had significantly greater negative functional connectivity between the left amygdala and bilateral vlPFC compared with subjects with BPI. ConclusionsThis study provides evidence that dysfunction in the neural networks responsible for emotion regulation, including the prefrontal cortex, cingulate, and subcortical structures, are present in BPI subjects, even while euthymic.

Report this publication

Statistics

Seen <100 times