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From SARS-CoV to SARS-CoV-2: safety and broad-spectrum are important for coronavirus vaccine development.

Authors
  • Ma, Cuiqing1
  • Su, Shan2
  • Wang, Jiachao1
  • Wei, Lin1
  • Du, Lanying3
  • Jiang, Shibo4
  • 1 Department of Immunology, Key Laboratory of Immune Mechanism and Intervention on Serious Disease in Hebei Province, Hebei Medical University, 050017, Shijiazhuang, China. , (China)
  • 2 Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China. , (China)
  • 3 Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, 10065, USA.
  • 4 Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China; Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, 10065, USA. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Microbes and infection
Publication Date
Jan 01, 2020
Volume
22
Issue
6-7
Pages
245–253
Identifiers
DOI: 10.1016/j.micinf.2020.05.004
PMID: 32437926
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The global pandemic of COVID-19 caused by SARS-CoV-2 (also known as 2019-nCoV and HCoV-19) has posed serious threats to public health and economic stability worldwide, thus calling for development of vaccines against SARS-CoV-2 and other emerging and reemerging coronaviruses. Since SARS-CoV-2 and SARS-CoV have high similarity of their genomic sequences and share the same cellular receptor (ACE2), it is essential to learn the lessons and experiences from the development of SARS-CoV vaccines for the development of SARS-CoV-2 vaccines. In this review, we summarized the current knowledge on the advantages and disadvantages of the SARS-CoV vaccine candidates and prospected the strategies for the development of safe, effective and broad-spectrum coronavirus vaccines for prevention of infection by currently circulating SARS-CoV-2 and other emerging and reemerging coronaviruses that may cause future epidemics or pandemics. Copyright © 2020 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

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