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From influenza infection to anti-ADAMTS13 autoantibodies via cross-reactivity

Authors
  • Kanduc, Darja
Type
Published Article
Journal
Infection International
Publisher
Sciendo
Publication Date
Apr 22, 2019
Volume
7
Issue
4
Pages
113–120
Identifiers
DOI: 10.2478/ii-2019-0002
Source
De Gruyter
Keywords
License
Green

Abstract

Autoantibodies (AAbs) against von Willebrand factor (vWF)-cleaving protease ADAMTS13 causally relate to thrombotic thrombocytopenic purpura (TTP). How anti-ADAMTS13 AAbs are generated is unknown. Starting from reports according to which influenza infection can trigger TTP by the production of ADAMTS13 AAbs, this study explores influenza viruses and ADAMTS13 protein for common peptide sequences that might underlie anti-influenza immune responses able to cross-react with ADAMTS13. Results document that numerous peptides are shared between influenza A and B viruses and ADAMTS13, thus supporting the hypothesis of cross-reactivity as a mechanism driving the generation of anti-ADAMTS13 AAbs.

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