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From imino sugars to cancer glycoproteins.

Authors
  • Paulsen, H
  • Brockhausen, I
Type
Published Article
Journal
Glycoconjugate journal
Publication Date
Jan 01, 2001
Volume
18
Issue
11-12
Pages
867–870
Identifiers
PMID: 12820720
Source
Medline
License
Unknown

Abstract

This review summarizes fifty years of carbohydrate chemistry, from studies of reaction mechanisms and development of synthetic methods to the design of specific compounds for investigations of cancer glycoproteins. Through these years of intensive research, many carbohydrate derivatives were shown to be biologically relevant, for example the fragments of bacterial polysaccharides and imino sugars that were potent inhibitors of glycosidases. Oligosaccharides and O- glycopeptides with GalNAc-Ser/Thr linkages were essential for studies of cancer immunology and the specificities and inhibition of cancer glycosyltransferases. Thus carbohydrate chemistry has provided the basis for our knowledge of the biochemistry and immunology of cancer cell glycoproteins.

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