Affordable Access

deepdyve-link
Publisher Website

From BDNF to reading: Neural activation and phonological processing as multiple mediators.

Authors
  • Mascheretti, Sara1
  • Perdue, Meaghan V2
  • Feng, Bei3
  • Andreola, Chiara4
  • Dionne, Ginette3
  • Jasińska, Kaja K5
  • Pugh, Kenneth R2
  • Grigorenko, Elena L6
  • Landi, Nicole7
  • 1 Child Psychopathology Unit, Scientific Institute, IRCCS E. Medea, Bosisio Parini, LC, Italy. , (Italy)
  • 2 Department of Psychological Sciences, University of Connecticut, Storrs, CT, USA; Haskins Laboratories, New Haven, CT, USA.
  • 3 School of Psychology, Université Laval, Québec, Canada. , (Canada)
  • 4 Child Psychopathology Unit, Scientific Institute, IRCCS E. Medea, Bosisio Parini, LC, Italy; Université de Paris, Laboratoire de Psychologie de Développement et de l'Éducation de l'Enfant (LaPsyDÉ), Paris, France. , (France)
  • 5 Haskins Laboratories, New Haven, CT, USA; Applied Psychology and Human Development, University of Toronto, Toronto, Canada. , (Canada)
  • 6 Haskins Laboratories, New Haven, CT, USA; Texas Institute for Measurement, Evaluation, and Statistics, University of Houston, Houston, TX, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA; St. Petersburg State University, Russia.
  • 7 Department of Psychological Sciences, University of Connecticut, Storrs, CT, USA; Haskins Laboratories, New Haven, CT, USA. Electronic address: [email protected]
Type
Published Article
Journal
Behavioural brain research
Publication Date
Aug 15, 2020
Volume
396
Pages
112859–112859
Identifiers
DOI: 10.1016/j.bbr.2020.112859
PMID: 32810467
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The BDNF gene is a prominent promoter of neuronal development, maturation and plasticity. Its Val66Met polymorphism affects brain morphology and function within several areas and is associated with several cognitive functions and neurodevelopmental disorder susceptibility. Recently, it has been associated with reading, reading-related traits and altered neural activation in reading-related brain regions. However, it remains unknown if the intermediate phenotypes (IPs, such as brain activation and phonological skills) mediate the pathway from gene to reading or reading disability. By conducting a serial multiple mediation model in a sample of 94 children (age 5-13), our findings revealed no direct effects of genotype on reading. Instead, we found that genotype is associated with brain activation in reading-related and more domain general regions which in turn is associated with phonological processing which is associated with reading. These findings suggest that the BDNF-Val66Met polymorphism is related to reading via phonological processing and functional activation. These results support brain imaging data and neurocognitive traits as viable IPs for complex behaviors. Copyright © 2020 Elsevier B.V. All rights reserved.

Report this publication

Statistics

Seen <100 times