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A frequent Toll-like receptor 1 gene polymorphism affects NK- and T-cell IFN-γ production and is associated with Helicobacter pylori-induced gastric disease.

Authors
  • Yang, Chin-An
  • Scheibenbogen, Carmen
  • Bauer, Sandra
  • Kleinle, Christoph
  • Wex, Thomas
  • Bornschein, Jan
  • Malfertheiner, Peter
  • Hellmig, Stephan
  • Schumann, Ralf R
  • Hamann, Lutz
Type
Published Article
Journal
Helicobacter
Publisher
Wiley (Blackwell Publishing)
Publication Date
Feb 01, 2013
Volume
18
Issue
1
Pages
13–21
Identifiers
DOI: 10.1111/hel.12001
PMID: 23067142
Source
Medline
License
Unknown

Abstract

In conclusion, our results suggest that the nonfunctional TLR1 602S/S genotype is associated with a reduced risk of H. pylori-induced gastric diseases, probably via diminished Th1 responses.

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