Frequent Promoter Methylation of CDH1, DAPK, RARB, and HIC1 Genes in Carcinoma of Cervix Uteri: Its Relationship to Clinical Outcome

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Frequent Promoter Methylation of CDH1, DAPK, RARB, and HIC1 Genes in Carcinoma of Cervix Uteri: Its Relationship to Clinical Outcome

Publisher
BioMed Central
Publication Date
May 13, 2003
Source
PMC
Keywords
Disciplines
  • Biology
  • Ecology
License
Unknown

Abstract

1476-4598-2-24.fm ral ss BioMed CentMolecular Cancer Open AcceResearch Frequent Promoter Methylation of CDH1, DAPK, RARB, and HIC1 Genes in Carcinoma of Cervix Uteri: Its Relationship to Clinical Outcome Gopeshwar Narayan1, Hugo Arias-Pulido2, Sanjay Koul1, Hernan Vargas3, Fang F Zhang4, Jeannine Villella5, Achim Schneider6, Mary B Terry4, Mahesh Mansukhani1 and Vundavalli V Murty*1,7 Address: 1Department of Pathology, Columbia University, New York, New York 10032, USA, 2Department of Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, New Mexico, USA, 3Department of Tumor Molecular Biology, Instituto Nacional de Cancerología, Bogotá, Colombia, 4Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, 10032, USA, 5Department of Obstetrics & Gynecology, Columbia University, New York, New York 10032, USA, 6Department of Obstetrics & Gynecology, Friedrich Schiller University, Jena, 07740, Germany and 7Institute for Cancer Genetics, College of Physicians & Surgeons of Columbia University, New York, New York 10032 Email: Gopeshwar Narayan - [email protected]; Hugo Arias-Pulido - [email protected]; Sanjay Koul - [email protected]; Hernan Vargas - [email protected]; Fang F Zhang - [email protected]; Jeannine Villella - [email protected]; Achim Schneider - [email protected]; Mary B Terry - [email protected]; Mahesh Mansukhani - [email protected]; Vundavalli V Murty* - [email protected] * Corresponding author cervical carcinomapromoter hypermethylationCDH1DAPKRARBtumor suppressor genegene expression Abstract Background: Cervical cancer (CC), a leading cause of cancer-related deaths in women worldwide, has been causally linked to genital human papillomavirus (HPV) infection. Although a host of genetic alterations have been identified, molecular basis of CC development is still poorly understood. Results: We examined the role of promoter hypermethylation, an epigenetic alte

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