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Frequent physical activity is associated with reduced risk of severe diabetic retinopathy in type 1 diabetes.

Authors
  • Tikkanen-Dolenc, Heidi1, 2, 3
  • Wadén, Johan1, 2, 3
  • Forsblom, Carol1, 2, 3
  • Harjutsalo, Valma1, 2, 3, 4
  • Thorn, Lena M1, 2, 3
  • Saraheimo, Markku1, 2, 3
  • Elonen, Nina1, 2, 3
  • Hietala, Kustaa5
  • Summanen, Paula5
  • Tikkanen, Heikki O6, 7
  • Groop, Per-Henrik8, 9, 10, 11
  • 1 Folkhälsan Institute of Genetics, Folkhälsan Research Center, Biomedicum Helsinki, Helsinki, Finland. , (Finland)
  • 2 Abdominal Center Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. , (Finland)
  • 3 Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland. , (Finland)
  • 4 The Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland. , (Finland)
  • 5 Department of Ophthalmology, Helsinki University Hospital, Helsinki, Finland. , (Finland)
  • 6 Department of Sports and Exercise Medicine, Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland. , (Finland)
  • 7 School of Medicine, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland. , (Finland)
  • 8 Folkhälsan Institute of Genetics, Folkhälsan Research Center, Biomedicum Helsinki, Helsinki, Finland. [email protected] , (Finland)
  • 9 Abdominal Center Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. [email protected] , (Finland)
  • 10 Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland. [email protected] , (Finland)
  • 11 Department of Diabetes, Central Clinical School, Monash University, Melbourne, VIC, Australia. [email protected] , (Australia)
Type
Published Article
Journal
Acta diabetologica
Publication Date
Nov 20, 2019
Identifiers
DOI: 10.1007/s00592-019-01454-y
PMID: 31749048
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The aim of this study was to investigate whether leisure-time physical activity (LTPA) is associated with the development of severe diabetic retinopathy in individuals with type 1 diabetes. Prospective observational analysis as part of the Finnish diabetic nephropathy (FinnDiane) Study with a mean follow-up time of 10.7 years was performed. A total of 1612 individuals with type 1 diabetes were recruited, and LTPA was assessed at baseline using a validated self-report questionnaire. Severe diabetic retinopathy was defined as the initiation of laser treatment due to severe nonproliferative, proliferative retinopathy or diabetic maculopathy (identified from the Care Register for Health Care). A total of 261 patients received laser treatment during the follow-up. Higher frequency of LTPA was associated with a lower incidence of severe diabetic retinopathy (p = 0.024), a finding that remained significant after adjustment for gender, duration, age at onset of diabetes, kidney function, BMI, triglycerides and systolic blood pressure. However, when HbA1c and smoking were added to the Cox regression model the association was no more significant. Frequent LTPA is associated with a lower incidence of severe diabetic retinopathy during the follow-up. The total amount or the other components of LTPA (intensity or duration of a single session) were not associated with severe diabetic retinopathy.

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