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Frequent co-expression of EGFR and NeuGcGM3 ganglioside in cancer: it's potential therapeutic implications.

Authors
  • Palomo, Addys González1
  • Santana, Rancés Blanco2
  • Pérez, Xiomara Escobar3
  • Santana, Damián Blanco3
  • Gabri, Mariano Rolando4
  • Monzon, Kalet León2
  • Pérez, Adriana Carr2
  • 1 Center of Molecular Immunology (CIM), 216 Street and 15 Avenue, Atabey, Playa, P.O. Box 16040, Habana, Cuba. [email protected]
  • 2 Center of Molecular Immunology (CIM), 216 Street and 15 Avenue, Atabey, Playa, P.O. Box 16040, Habana, Cuba.
  • 3 Department of Cell Biology and Tissues Banking, National Institute of Oncology and Radiology, 29 and F Street, Vedado, Plaza de la Revolución, P.O. Box 10400, Havana, Cuba.
  • 4 Laboratory of Molecular Oncology, Quilmes National University, R. Sáenz Peña 180, P.O. Box B1876BXD, Buenos Aires, Argentina.
Type
Published Article
Journal
Clinical & Experimental Metastasis
Publisher
Springer-Verlag
Publication Date
October 2016
Volume
33
Issue
7
Pages
717–725
Identifiers
DOI: 10.1007/s10585-016-9811-0
PMID: 27449755
Source
Medline
Keywords
License
Unknown

Abstract

Interaction between epidermal growth factor receptor (EGFR) signaling with GM3 ganglioside expression has been previously described. However, little is known about EGFR and NeuGcGM3 co-expression in cancer patients and their therapeutic implications. In this paper, we evaluate the co-expression of EGFR and NeuGcGM3 ganglioside in tumors from 92 patients and in two spontaneous lung metastasis models of mice (Lewis lung carcinoma (3LL-D122) in C57BL/6 and mammary carcinoma (4T1) in BALB/c). As results, co-expression of EGFR and NeuGcGM3 ganglioside was frequently observed in 63 of 92 patients (68 %), independently of histological subtype. Moreover, EGFR is co-expressed with NeuGcGM3 ganglioside in the metastasis of 3LL-D122 and 4T1 murine models. Such dual expression appears to be therapeutically relevant, since combined therapy with mAbs against these two molecules synergistically increase the survival of mice treated. Overall, our results suggest that NeuGcGM3 and EGFR may coordinately contribute to the tumor cell biology and that therapeutic combinations against these two targets might be a valid strategy to explore.

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