1. The structural malformations of hypothalamo-pituitary region were found in 42% of patients. 2. The diagnosis of multihormonal hypopituitarism in a patient is connected with an increased risk of the presence of severe structural abnormalities in hypothalamo-pituitary region. 3. IGF-1 level and maximal GH secretion are negatively correlated with the presence of malformations of the hypothalamo-pituitary region.