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Frequency of RHD variants in serologically weak D Turkish blood donors.

Authors
  • Yanasik, Melek1
  • Oguz, Fatma Savran2
  • Besisik, Sevgi Kalayoglu3
  • Huslu, Mukadder1
  • Ozturk, Gulyuz4
  • Temurhan, Sonay5
  • Aydin, Filiz6
  • 1 Istanbul Medical Faculty Hospital Blood Center, Istanbul University, Istanbul, Turkey. , (Turkey)
  • 2 Istanbul Medical Faculty, Department of Medical Biology, Istanbul University, Istanbul, Turkey. Electronic address: [email protected] , (Turkey)
  • 3 Istanbul Medical Faculty, Department of Hematology, Istanbul University, Turkey. , (Turkey)
  • 4 Department of Pediatric Hematology/Oncology & Bone Marrow Transplantation Unit, School of Medicine, Altunizade Hospital, Acıbadem University, Istanbul, Turkey. , (Turkey)
  • 5 Istanbul Medical Faculty, Department of Medical Biology, Istanbul University, Istanbul, Turkey. , (Turkey)
  • 6 Istanbul Science University, Department of Medical Biology, Istanbul, Turkey. , (Turkey)
Type
Published Article
Journal
Transfusion and Apheresis Science
Publisher
Elsevier
Publication Date
Apr 01, 2021
Volume
60
Issue
2
Pages
103024–103024
Identifiers
DOI: 10.1016/j.transci.2020.103024
PMID: 33308979
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

RhD typing has remained of primary importance, as being the leading cause of hemolytic disease of the newborn. Among Rh system's 55 blood group antigens, RhD is the most immunogenic. We aimed with this study to determine weak D/partial D variant frequency in blood donors who were admitted to our blood center and have serologically designated blood group weak D. We screened blood donors who admitted between 2011 and 2017 to our blood center. Sixty-seven serologically weak D phenotyped donors have participated in the study. These donors' samples were studied further by Polymerase Chain Reaction Sequence- Specific Primers (PCR-SSP) for determining D variants. Weak D phenotype was detected in 228(0.12 %) out of 177,554 donors. Sixty-seven of them agreed to take part in the study. The frequency of weak D and partial D was 68.7 % (n = 46), and 22.4 % (n = 15), in order. The most encountered weak D and partial D variant was type 15 and DFR type, respectively. The prevalence of serologically weak D phenotypes varies by race and ethnicity. Turkey is a country covering a mixture of European and Asian DNA with different ethnic groups. Thus, our research as giving the overall distribution of RHD variants from the largest city of Turkey, which may reflect the general ethnic background of the country, would help to the establishment of a databank for blood banking. This paper is the first molecular study on RHD variants in Turkey. New molecular research would be more reliable and precise. Copyright © 2020 Elsevier Ltd. All rights reserved.

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