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Frequency of Hepatitis B Virus Envelope Antigen and Antibodies Among Chronic Carriers in Ibadan, Nigeria.

Authors
  • Farinloye, Omobobola Idowu1, 2
  • Otunola, Adedayo2
  • Fowotade, Adeola3
  • Faneye, Adedayo Omotayo4
  • 1 Department of Pathology, University College Hospital, Ibadan, Nigeria. , (Niger)
  • 2 Department of Bioscience and Biotechnology, Kwara State University, Malete. Nigeria. , (Niger)
  • 3 Department of Medical Microbiology and College of Medicine, University of Ibadan, Ibadan, Nigeria. , (Niger)
  • 4 Department of Virology, College of Medicine, University of Ibadan, Ibadan, Nigeria. , (Niger)
Type
Published Article
Journal
Viral Immunology
Publisher
Mary Ann Liebert
Publication Date
May 01, 2021
Volume
34
Issue
4
Pages
284–287
Identifiers
DOI: 10.1089/vim.2020.0259
PMID: 33999720
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Hepatitis B virus (HBV) infection is a major health challenge in sub-Saharan Africa with a prevalence rate of >7%. It is an important clinical problem due to its potential adverse sequelae, including hepatocellular carcinoma. The additional challenge of its associated chronic infection makes its prevention difficult despite the widely available vaccine. Infectious chronic HBV carriers are likely to be the most common source of HBV infection in the community. This study aims to study the degree of infectiousness of HBV carriers by testing for HBV envelope antigen (HBeAg) and antibody among HBV carriers attending the gastrointestinal clinic at University College Hospital (UCH, Ibadan, Nigeria). This is a cross-sectional study among 129 consecutively recruited HBV infected individuals who gave informed consent to participate in the study. The participants of the study were recruited from clients attending the gastrointestinal clinic of UCH. The sera obtained from the participants were tested for HBsAg, HBeAg, and antibodies to HBV envelope antibodies (HBeAb) using commercially available enzyme-linked immunosorbent assay (ELISA) test kits by DIA.PRO (Diagnostic Bioprobes Srl, Milan, Italy) according to the manufacturer's instruction. Of 129 samples collected, 63 (48.8%) tested positive for HBeAg, whereas 72 (55.8%) tested positive for HBeAb (p = 0.012); HBeAg prevalence was higher in females than males and also prevalent among the age group of 31-40 years. Seventy-four (57.4%) of the participants also tested positive for both HBeAg and HBeAb, whereas 55 (42.6%) were negative for both. This study shows that there is a high level of infectiousness among HBsAg-positive individuals in Ibadan, Nigeria.

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