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Frequency of elemental events of intracellular Ca(2+) dynamics.

Authors
Type
Published Article
Journal
Physical review. E, Statistical, nonlinear, and soft matter physics
Publication Date
Volume
73
Issue
6 Pt 1
Pages
61923–61923
Identifiers
PMID: 16906880
Source
Medline
License
Unknown

Abstract

The dynamics of intracellular Ca(2+) is driven by random events called Ca(2+) puffs, in which Ca(2+) is liberated from intracellular stores. We show that the emergence of Ca(2+) puffs can be mapped to an escape process. The mean first passage times that correspond to the stochastic fraction of puff periods are computed from a novel master equation and two Fokker-Planck equations. Our results demonstrate that the mathematical modeling of Ca(2+) puffs has to account for the discrete character of the Ca(2+) release sites and does not permit a continuous description of the number of open channels.

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