Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population

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Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population

Publisher
BioMed Central
Publication Date
Mar 14, 2007
Source
PMC
Keywords
Disciplines
  • Biology
  • Design
  • Medicine
License
Unknown

Abstract

1471-2156-8-7.fm ral ss BioMed CentBMC Genetics Open AcceResearch article Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population Han-Yao Huang*1, Lucy Thuita2, Paul Strickland3, Sandra C Hoffman1, George W Comstock1 and Kathy J Helzlsouer1,4 Address: 1Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA, 2Department of Biostatistics & Epidemiology/Wb4, Cleveland Clinic Foundation, Cleveland, Ohio, USA, 3Department of Environmental Health Sciences, Johns Hopkins School of Public Health, Baltimore, Maryland, USA and 4Prevention and Research Center, Women's Center for Health & Medicine, Mercy Medical Center, Baltimore, Maryland, USA Email: Han-Yao Huang* - [email protected]; Lucy Thuita - [email protected]; Paul Strickland - [email protected]; Sandra C Hoffman - [email protected]; George W Comstock - [email protected]; Kathy J Helzlsouer - [email protected] * Corresponding author Abstract Background: Allele frequencies reported from public databases or articles are mostly based on small sample sizes. Differences in genotype frequencies by age, race and sex have implications for studies designed to examine genetic susceptibility to disease. In a community-based cohort of 9,960 individuals, we compared the allele frequencies of 49 single nucleotide polymorphisms (SNPs) of genes involved in inflammatory pathways to the frequencies reported on public databases, and examined the genotypes frequencies by age and sex. The genes in which SNPs were analyzed include CCR2, CCR5, COX1, COX2, CRP, CSF1, CSF2, IFNG, IL1A, IL1B, IL2, IL4, IL6, IL8, IL10, IL13, IL18, LTA, MPO, NOS2A, NOS3, PPARD, PPARG, PPARGC1 and TNF. Results: Mean(SD) age was 53.2(15.5); 98% were Caucasians and 62% were women. Only 1 out of 33 SNPs differed from the SNP500Cancer database in allele frequency by >10% in Caucasians (n = 9,831), whereas 12 SNPs differed by >10% (up to 50%) in African

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