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Free and total carnitine in human serum after oral ingestion of L-carnitine.

Authors
  • Bach, A C
  • Schirardin, H
  • Sihr, M O
  • Storck, D
Type
Published Article
Journal
Diabète & métabolisme
Publication Date
Jan 01, 1983
Volume
9
Issue
2
Pages
121–124
Identifiers
PMID: 6617931
Source
Medline
License
Unknown

Abstract

Twelve students with in apparent good health and fasting since the previous evening ingested 2 g of L-carnitine on one day and a placebo on another day in a single-blind trial. Six blood samples were taken during the 24 h following the ingestion. Their blood carnitine levels increased (the free form by 81%, and the total by 57%) to a maximum at about 3.5 h and then slowly decreased. Twenty-four hours after ingestion, blood carnitine concentrations had still not returned to their initial levels. In the time interval where the decay curve approximated a single exponential, the half-life of the carnitine appeared to be of the order of 15 h. During the 24 h after the administration of the 2 g of L-carnitine, 7% +/- 1% of it was eliminated in the urine. This work suggest that the daily administration during a long period, of 2 g of L-carnitine guarantee in a healthy subject blood carnitine concentrations superior to the normal levels. Its remains to determine if the dose is sufficient in the case where L-carnitine is given to ameliorate a primary or secondary lack of carnitine, or to lower a high level of lipids in blood.

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