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Fragment-based approach to novel bioactive purine derivatives

Authors
  • Krasnov, Victor P.1, 2
  • Levit, Galina L.1
  • Musiyak, Vera V.1
  • Gruzdev, Dmitry A.1, 2
  • Charushin, Valery N.1, 2
  • 1 Russian Academy of Sciences Ural Branch, Postovsky Institute of Organic Synthesis, 22/20 S.Kovalevskoy/Akademicheskaya St. , (Russia)
  • 2 Ural Federal University named after the first President of Russia B N Yeltsin, Institute of Chemical Engineering, Russia , (Russia)
Type
Published Article
Journal
Pure and Applied Chemistry
Publisher
Walter de Gruyter GmbH
Publication Date
Jul 13, 2020
Volume
92
Issue
8
Pages
1277–1295
Identifiers
DOI: 10.1515/pac-2019-1214
Source
De Gruyter
Keywords
License
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Abstract

Using purine as a scaffold, the methods for preparation of novel 2-aminopurine and purine derivatives substituted at position C 6 by the fragments of natural amino acids, short peptides, and N-heterocycles, including enantiopure ones, have been proposed. The methods for determination of the enantiomeric purity of the obtained chiral compounds have been developed. Conjugates exhibiting high antimycobacterial or anti-herpesvirus activity against both laboratory and multidrug-resistant strains were revealed among the obtained compounds.

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