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Fractional CO2 laser treatment for burn scar improvement: A systematic review and meta-analysis.

Authors
  • Choi, Katherine J1
  • Williams, Eva A2
  • Pham, Christopher H2
  • Collier, Zachary J2
  • Dang, Justin3
  • Yenikomshian, Haig A4
  • Gillenwater, T Justin5
  • 1 Division of Plastic and Reconstructive Surgery, Keck School of Medicine of University of Southern California, Los Angeles, CA, United States; Keck School of Medicine of University of Southern California, Los Angeles, CA, United States. , (United States)
  • 2 Division of Plastic and Reconstructive Surgery, Keck School of Medicine of University of Southern California, Los Angeles, CA, United States. , (United States)
  • 3 Los Angeles County/University of Southern California Medical Center, Los Angeles, CA, United States. , (United States)
  • 4 Division of Plastic and Reconstructive Surgery, Keck School of Medicine of University of Southern California, Los Angeles, CA, United States; Keck School of Medicine of University of Southern California, Los Angeles, CA, United States; Los Angeles County/University of Southern California Medical Center, Los Angeles, CA, United States. , (United States)
  • 5 Division of Plastic and Reconstructive Surgery, Keck School of Medicine of University of Southern California, Los Angeles, CA, United States; Keck School of Medicine of University of Southern California, Los Angeles, CA, United States; Los Angeles County/University of Southern California Medical Center, Los Angeles, CA, United States. Electronic address: [email protected] , (United States)
Type
Published Article
Journal
Burns : journal of the International Society for Burn Injuries
Publication Date
Nov 09, 2020
Identifiers
DOI: 10.1016/j.burns.2020.10.026
PMID: 33288326
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Burn injury can cause abnormal healing and pathologic scar formation that significantly impairs patients' ability to return to baseline levels of functioning. Quality of life can be significantly diminished due to pain, stiffness, contracture, and the psychological burden of disfigurement. Traditional scar therapies such as silicone sheeting and compression garments are highly reliant on patient compliance, and have not demonstrated satisfactory efficacy. Even more invasive therapies such as intralesional medication delivery or surgical contracture release have high recurrence rates. Recently, fractional CO2 laser therapy has emerged as a promising treatment modality for burn scars, but there is a lack of recent studies that aggregates extant data to demonstrate outcomes after laser therapy. To address this, we conducted a systematic review and meta-analysis to determine the efficacy of fractional CO2 lasers in treating burn scars, and found that laser therapy alone yielded statistically significant improvements in scar profiles. There were very few reports of adverse effects, most treatments were provided as outpatient, and both patient and burn practitioners reported high satisfaction. By sharing our findings, we hope that more burn practitioners will consider adopting laser therapy as a safe and cost-effective first-line therapy for burn scar management. Copyright © 2020. Published by Elsevier Ltd.

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