In this study, four new species of Onosma subsect. Asterotricha from Northwest, West and North of Iran are described and illustrated. An extensive review of literature and a comparative study with specimens from several herbaria lead to determine these new species. Our argument for mentioned innovations is the significant divergence in the most important morphological characters. A diagnostic key to the new species as well Asterotrichous members of the genus known from Flora Iranica region is provided. In addition, detailed description and distribution as well as comparison tables with closely related species, are included.