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Four new phenanthrene derivatives from Bulbophyllum retusiusculum.

Authors
  • Fang, Yun-Shan1
  • Yang, Ming-Hui2
  • Wang, Jia-Peng3
  • Fu, Huan2
  • Cai, Le4
  • Ding, Zhong-Tao5
  • 1 School of Chemistry and Chemical Engineering, Kunming University, Kunming 650214, China. , (China)
  • 2 College of pharmacy, Dali University, Dali 671000, China. , (China)
  • 3 Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China. , (China)
  • 4 Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China. Electronic address: [email protected] , (China)
  • 5 Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China; College of pharmacy, Dali University, Dali 671000, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Fitoterapia
Publication Date
Jul 01, 2021
Volume
152
Pages
104910–104910
Identifiers
DOI: 10.1016/j.fitote.2021.104910
PMID: 33905817
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Three new dihydrophenanthrenes, retusiusine D (1), retusiusine E (2), retusiusine F (3), and a new phenanthrene retusiusine G (4), together with two known dihydrophenanthrenes 4,7-dihydroxy-2,3-methylenedioxy-9,10-dihydrophenanthrene (5) and epemeranthol-A (6) were isolated from the tubers of Bulbophyllum retusiusculum. Their structures were established on the basis of extensive spectroscopic analyses. Compounds 1 and 2 exhibited potent cytotoxic activities against SMMC-7721 and weak cytotoxic activities against HL-60. Compound 4 showed moderate cytotoxic activity against SMMC-7721 and MCF-7. Copyright © 2021 Elsevier B.V. All rights reserved.

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