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Fosfomycin Alters Lipopolysaccharide-Induced Inflammatory Cytokine Production in Mice

Authors
  • Tetsuya Matsumoto
  • Kazuhiro Tateda
  • Shuichi Miyazaki
  • Nobuhiko Furuya
  • Akira Ohno
  • Yoshikazu Ishii
  • Yoichi Hirakata
  • Keizo Yamaguchi
Publisher
American Society for Microbiology
Publication Date
Mar 01, 1999
Source
PMC
Keywords
License
Unknown

Abstract

To determine the mechanisms of immunomodulating action of fosfomycin (FOF), we examined its effect on the production of inflammatory cytokines in mice injected with lipopolysaccharide (LPS). Treatment with FOF significantly lowered the peak serum levels of tumor necrosis factor alpha and interleukin-1β, indicating that FOF alters inflammatory cytokine production after LPS stimulation.

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