Destructive behavior at work is one of the most important research topics affecting organizational performance standards and well-being. The article presented a scientific literature analysis and synthesis as well as the authors insight into destructive relationships in the work environment. There a various forms of destructive relationship in a workplace: mobbing, rare bullying, discrimination, nepotism, favoritism, cronyism, social ostracism, social loafing, organizational cynicism, depersonalization and cyber loafing. Destructive relationships shape the work environment has a negative impact on productivity, motivation, job satisfaction, health and promotes resignation. Destructive relationships among employees are explored in various sectors like transport and logistics, restaurants and catering, telecommunications, education and science and others.