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Formal agent-based modelling of intracellular chemical interactions.

Authors
Type
Published Article
Journal
Biosystems
0303-2647
Publisher
Elsevier
Publication Date
Volume
85
Issue
1
Pages
37–45
Identifiers
PMID: 16581178
Source
Medline
License
Unknown

Abstract

Individual-based or agent-based models have proved useful in a variety of different biological contexts. This paper presents an agent-based model using a formal computational modelling approach to model a crucial biological system--the intracellular NF-kappaB signalling pathway. The pathway is vital to immune response regulation, and is fundamental to basic survival in a range of species. Alterations in pathway regulation underlie many diseases, including atherosclerosis and arthritis. Our modelling of individual molecules, receptors and genes provides a more comprehensive outline of regulatory network mechanisms than previously possible with equation-based approaches. The model has been validated with data obtained from single cell experimental analysis.

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