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Form from Function, Order from Chaos in Male Germline Chromatin

Authors
  • Ellis, Peter J. I.
  • Griffin, Darren K.
Type
Published Article
Journal
Genes
Publisher
MDPI AG
Publication Date
Feb 18, 2020
Volume
11
Issue
2
Identifiers
DOI: 10.3390/genes11020210
PMID: 32085642
PMCID: PMC7073629
Source
PubMed Central
Keywords
License
Green

Abstract

Spermatogenesis requires radical restructuring of germline chromatin at multiple stages, involving co-ordinated waves of DNA methylation and demethylation, histone modification, replacement and removal occurring before, during and after meiosis. This Special Issue has drawn together papers addressing many aspects of chromatin organization and dynamics in the male germ line, in humans and in model organisms. Two major themes emerge from these studies: the first is the functional significance of nuclear organisation in the developing germline; the second is the interplay between sperm chromatin structure and susceptibility to DNA damage and mutation. The consequences of these aspects for fertility, both in humans and other animals, is a major health and social welfare issue and this is reflected in these nine exciting manuscripts.

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