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Forging new ties between E. coli genes.

Authors
Type
Published Article
Journal
Cell
Publisher
Elsevier
Volume
133
Issue
7
Pages
1135–1137
Identifiers
DOI: 10.1016/j.cell.2008.06.003
Source
Ideker Lab
License
Unknown

Abstract

A recent study in Nature (Isalan et al., 2008) has examined the effects of systematically adding new transcriptional interactions in the bacterium Escherichia coli. Surprisingly, the majority of the engineered connections have no effect on growth, and in some cases the new connections enhance fitness. These findings reveal insights into the robustness and evolvability of gene networks.

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