Abstract : Muscle strength is a physical valence required for carrying out daily activities, whether in the leisure, work or physical performance. Low levels of muscle strength are associated with worse clinical outcomes, physical dependence and non-communicable diseases. To measure muscular strength levels of individuals has great relevance in the field of public health, since besides the low cost and ease of data collection, the results help to prevent health problems. The overall objective of the study was to analyze the association between handgrip strength and sociodemographic factors and lifestyle in young adults and the elderly. To identify gaps in scientific object of study was initially conducted systematic review in Pubmed, Ebsco, Scielo, Web of Science, Scopus, and Lilacs. The analytical population-based study was developed with 852 participants (25-65 years) from Florianópolis, SC, Brazil. The handgrip strength (HGS) was assessed by handgrip continuously and subsequently distributed into tertiles, classified as a low force (first tertile) and adequate strength (second and third tertile). The independent variables were gender, age, per capita income, smoking, sleep/day and physical activity in leisure, locomotion, work and domestic activities. It is used multiple linear regression to identify the predictors of HGS and binary logistic regression to estimate the odds ratios and 95% confidence intervals. As a result of the systematic review, it was found that the older adult, female and not physically active had lower handgrip strength levels. The survey of adults and young aged from Florianópolis / SC, found that women, older age individuals, increase the years of life in men and being inactive or insufficiently physically active during leisure time were the factors associated with lower handgrip values. It was found that compared to the investigated young, those aged greater than or equal to 50 had respectively 154% (OR: 2.54; CI: 1.13 to 5.66) and 260% (OR: 3.60 CI: 1.65 to 7.89) more likely to have low levels of FPM. Considering direct association with health diseases, efforts to increase grip strength levels should be emphasized in women, high age of individuals and not physically active.