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Food intake biomarkers for berries and grapes

  • Ulaszewska, M.1, 2
  • Garcia-Aloy, M.3, 4
  • Vázquez-Manjarrez, N.5, 6, 7
  • Soria-Florido, M. T.3
  • Llorach, R.3, 4
  • Mattivi, F.1, 8
  • Manach, C.5
  • 1 Fondazione Edmund Mach, Research and Innovation Centre Food Quality and Nutrition, Via Mach 1, San Michele all’Adige, 38010, Italy , San Michele all’Adige (Italy)
  • 2 IRCCS San Raffaele Scientific Institute, Milan, Italy , Milan (Italy)
  • 3 University of Barcelona, Barcelona, Spain , Barcelona (Spain)
  • 4 Instituto de Salud Carlos III, Barcelona, Spain , Barcelona (Spain)
  • 5 Université Clermont Auvergne, INRAE, UNH, F-63000, Clermont–Ferrand, France , Clermont–Ferrand (France)
  • 6 University of Copenhagen, Copenhagen, Denmark , Copenhagen (Denmark)
  • 7 Instituto Nacional de Ciencias Médicas y Nutrición Slavador Zubiran, Mexico City, Mexico , Mexico City (Mexico)
  • 8 University of Trent, Trento, Italy , Trento (Italy)
Published Article
Genes & Nutrition
Publication Date
Sep 23, 2020
DOI: 10.1186/s12263-020-00675-z
Springer Nature


Grapes and berries are two types of widely consumed fruits characterized by a high content in different phytochemicals. However, their accurate dietary assessment is particularly arduous, because of the already wide recognized bias associated with self-reporting methods, combined with the large range of species and cultivars and the fact that these fruits are popularly consumed not only in fresh and frozen forms but also as processed and derived products, including dried and canned fruits, beverages, jams, and jellies. Reporting precise type and/or quantity of grape and berries in FFQ or diaries can obviously be affected by errors. Recently, biomarkers of food intake (BFIs) rose as a promising tool to provide accurate information indicating consumption of certain food items. Protocols for performing systematic reviews in this field, as well as for assessing the validity of candidate BFIs have been developed within the Food Biomarker Alliance (FoodBAll) Project. This paper aims to evaluate the putative BIFs for blueberries, strawberries, raspberries, blackberries, cranberries, blackcurrant, and grapes. Candidate BFIs for grapes were resveratrol metabolites and tartaric acid. The metabolites considered as putative BFI for berries consumption were mostly anthocyanins derivatives together with several metabolites of ellagitannins and some aroma compounds. However, identification of BFIs for single berry types encountered more difficulties. In the absence of highly specific metabolites reported to date, we suggested some multi-metabolite panels that may be further investigated as putative biomarkers for some berry fruits.

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