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Food and fasting absorption of a single dose of a sustained release theophylline sprinkle formulation in children.

Authors
  • Pedersen, S
  • Steffensen, G
Type
Published Article
Journal
Allergy
Publication Date
Jan 01, 1986
Volume
41
Issue
1
Pages
46–50
Identifiers
PMID: 3963315
Source
Medline
License
Unknown

Abstract

The bioavailability and absorption pattern of theophylline from a single dose of a slow release theophylline sprinkle product (Somophyllin) were investigated in 10 asthmatic children both in fasting conditions and after a standardized breakfast. Theophylline given intravenously was used as a reference. The fasting absorption of Somophyllin was rather fast with peak serum theophylline levels 3-5 h (mean 3.7 h) after dosing. Food produced a small but statistically significant reduction in the rate of absorption of theophylline, so that the mean time to peak serum theophylline level was 5.6 h (range 4-8 h) after food. In no case was there any important difference between the absorption profiles on the test days, and the bioavailability was complete after both fasted and fed intake of the product (92.5% and 105%, respectively). It is suggested that to obtain the optimum absorption profile children should take Somophyllin with food rather than between meals.

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