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A follow-up study of the family with the Swedish APP 670/671 Alzheimer's disease mutation.

Authors
  • Wahlund, L O
  • Basun, H
  • Almkvist, O
  • Julin, P
  • Axelman, K
  • Shigeta, M
  • Jelic, V
  • Nordberg, A
  • Lannfelt, L
Type
Published Article
Journal
Dementia and geriatric cognitive disorders
Publication Date
Jan 01, 1999
Volume
10
Issue
6
Pages
526–533
Identifiers
PMID: 10559570
Source
Medline
License
Unknown

Abstract

In this familial form of AD a reduced temporal lobe glucose metabolism was indicative of AD before the expected clinical onset. Reduced glucose metabolism even preceded the development of subjective or objective cognitive dysfunction and might therefore serve as a clinical marker for AD before the onset of clinical symptoms. Reduced cerebral blood flow in the temporal lobes and cognitive deterioration paralleled the clinical decline in the early stage of the disease. Copyrightz1999S.KargerAG,Basel

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