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Follow the fatty brick road: lipid signaling in cell migration.

Authors
  • Renault, Andrew D
  • Lehmann, Ruth
Type
Published Article
Journal
Current Opinion in Genetics & Development
Publisher
Elsevier
Publication Date
Aug 01, 2006
Volume
16
Issue
4
Pages
348–354
Identifiers
PMID: 16806899
Source
Medline
License
Unknown

Abstract

Lysophospholipids play important roles in the migration of lymphocytes, smooth muscle cells and germ cells in vertebrates and invertebrates. In vertebrates, the migratory responses are mediated by specific G-protein-coupled receptors. These are expressed in both migrating lymphocyte and smooth muscle cells, and in their surrounding cells. In Drosophila germ cell migration, lipid phosphatases also act in both the surrounding and the migrating cells. In all three scenarios, the contributions of these genes in the stationary and migrating cells are being teased apart by genetic studies and direct observation, with exciting results.

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