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Follicle-stimulating hormone (FSHβ) gene polymorphisms and associations with reproductive traits in Rex rabbits.

Authors
  • Niu, Xiaoyan1
  • Martin, Graeme B2
  • Liu, Wenzhong3
  • Henryon, Mark A2
  • Ren, Keliang4
  • 1 College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu 030801, China; Institute of Animal Husbandry and Veterinary Medicine, Shanxi Academy of Agricultural Sciences, Taiyuan 030006, China. , (China)
  • 2 UWA Institute of Agriculture, University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia. , (Australia)
  • 3 College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu 030801, China. Electronic address: [email protected] , (China)
  • 4 Institute of Animal Husbandry and Veterinary Medicine, Shanxi Academy of Agricultural Sciences, Taiyuan 030006, China. , (China)
Type
Published Article
Journal
Animal reproduction science
Publication Date
Aug 01, 2019
Volume
207
Pages
36–43
Identifiers
DOI: 10.1016/j.anireprosci.2019.05.013
PMID: 31213331
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Follicle-stimulating hormone (FSH) stimulates granulosa cell proliferation and controls the development and maturation of oocytes. In this study with Rex rabbit, there was exploration of the relationships between reproductive traits and SNPs and haplotypes of FSHβ, and tested whether FSHβ SNPs would segregate between two lines, using 70 females from the White line and 100 females from the Beaver line. Three SNPs (FSH2, FSH30, FSH31) in exon1 and exon3 of FSHβ were strongly associated with reproductive traits in the combined population. For FSH2, the GG variant was associated with greater (P < 0.05) values for total number born (TNB) and number born alive (NBA), compared to those with the TT variant. For FSH30, for the AA variant there was greater (P < 0.05) values for TNB and NBA than with the GG and AG variants. For FSH31, the GG variant was associated with greater (P < 0.05) values for TNB, litter weight at birth (LWB) and litter size at 21 days of age (LS21), than the AG variant, and with greater (P < 0.01) values for NBA than the AG variant. When analyzed separately, FSH2 SNP was associated with LW21 in the Beaver line (P < 0.05), whereas FSH30 and FSH31 SNPs were associated with TNB and NBA in the White line (P < 0.05). It is concluded that genetic variation in FSHβ gene is associated with reproductive traits in the Rex rabbit, therefore, the FSH2, FSH30 and FSH31 SNPs can be used as molecular markers in genetic selection of rabbits. Copyright © 2019 Shanxi Agricultural University. Published by Elsevier B.V. All rights reserved.

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