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Folding makes an imprint.

Authors
  • Stricker, Stefan H1
  • 1 Reprogramming and Regeneration, Biomedical Center (BMC), Physiological Genomics, Faculty of Medicine, Ludwig Maximilian University (LMU) Munich, Planegg-Martinsried 82152, Germany; Epigenetic Epigenetic Engineering, Institute of Stem Cell Research, Helmholtz Zentrum, German Research Center for Environmental Health, Planegg-Martinsried 82152, Germany [email protected]. , (Germany)
Type
Published Article
Journal
Genes & development
Publication Date
Sep 01, 2023
Volume
37
Issue
17-18
Pages
779–780
Identifiers
DOI: 10.1101/gad.351216.123
PMID: 37821108
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Imprinted gene clusters are confined genomic regions containing genes with parent-of-origin-dependent transcriptional activity. In this issue of Genes & Development, Loftus and colleagues (pp. 829-843) made use of an insightful combination of descriptive approaches, genetic manipulations, and epigenome-editing approaches to show that differences in nuclear topology precede the onset of imprinted expression at the Peg13-Kcnk9 locus. Furthermore, the investigators provide data in line with a model suggesting that parent-of-origin-specific topological differences could be responsible for parent-of-origin-specific enhancer activity and thus imprinted expression. © 2023 Stricker; Published by Cold Spring Harbor Laboratory Press.

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