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The focal adhesion protein Integrin-Linked Kinase (ILK) as an important player in breast cancer pathogenesis

Authors
  • Tsirtsaki, Katerina1
  • Gkretsi, Vasiliki1
  • 1 European University Cyprus, Cyprus , (Cyprus)
Type
Published Article
Journal
Cell Adhesion & Migration
Publisher
Landes Bioscience
Publication Date
Oct 12, 2020
Volume
14
Issue
1
Pages
204–213
Identifiers
DOI: 10.1080/19336918.2020.1829263
PMID: 33043811
PMCID: PMC7553581
Source
PubMed Central
Keywords
License
Green

Abstract

Cell-extracellular matrix interactions, or focal adhesions (FA), are crucial for tissue homeostasis but are also implicated in cancer. Integrin-Linked Kinase (ILK) is an abundantly expressed FA protein involved in multiple signaling pathways. Here, we reviewed the current literature on the role of ILK in breast cancer (BC). Articles included in vitro and in vivo experiments as well as studies in human BC samples. ILK attenuation via silencing or pharmaceutical inhibition, leads to apoptosis or inhibition of epithelial-to-mesenchymal transition, and cell invasion whereas ILK overexpression suppresses anoikis and promotes tumor growth and metastasis. Finally, ILK is upregulated in BC tumors and its expression is associated with grade, and metastasis. Therefore, ILK should be evaluated as a potential anti-cancer pharmaceutical target.

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